Hyaluronic acid – is it really that miraculous?

Constantly we are reminded in different advertisements of hyaluronic acid and how great and skin improving it is. This compound is said to penetrate the skin deeply, keeping the natural moist in the skin at place while refining the skin and remove wrinkles. Anyway, is all of it true?


If you look at hyaluronic acid’s structural chemistry in the picture below, you will observe that it’s a highly polar molecule, with a lot of OH-groups and acid-groups, that can deprotonate in water. Therefore, you have an extremely water-soluble substance. The skin, on the other hand, is mostly hydrophobic (water-insoluble).




Regarding the above information, hyaluronic acid will not pass through the lipid layers in the skin. On the other hand, it will remain on the surface of the skin, not being able to penetrate the skin layers below.

In conclusion, I think that hyaluronic acid is very overrated. We need something better and more efficient. Isn’t that right?